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1Department of Medical Oncology, University Hospital Groningen, The NetherlandsCorrespondence to: Dr NH Mulder, Division of Medical Oncology, Department of Internal Medicine, University Hospital Groningen, PO Box 30.001, 9700 RB Groningen, The NetherlandsReinfusion of autologous hematopoietic peripheral blood stem cells (PBSC) or bone marrow is often accompanied by flushing, dyspnea, abdominal cramping, nausea and diarrhea. These symptoms and the observation that they can be prevented by ondansetron, a selective 5 HT3 receptor antagonist, led to the assumption that these side effects are due to infusion of free serotonin during the reinfusion of PBSC or bone marrow. Twenty five patients with solid tumors received, after myeloblative chemotherapy, a total of 30 reinfusions of PBSC canada goose jackets for sale and/or bone canada goose jackets prices marrow. In 17 patients, serotonin levels in the bags containing the PBSC were measured. In all patients, platelet serotonin levels were determined before and 1 h post reinfusion. In addition, before and 24 h after reinfusion urine was collected for determination of 5 hydroxyindole acetic acid (5 HIAA) and serotonin concentrations. Mean total volume reinfused was 471 185 ml. Neither 24 h cheap canada goose jackets uk urinary 5 HIAA nor serotonin levels were affected. These results indicate that reinfusion of PBSC or bone marrow is accompanied by substantial infusion of free serotonin, which might explain the observed side effects and justify the use of 5 HT3 receptor antagonists as pre medication for this procedure.
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